Your cells stop listening.
With insulin resistance, your cells don't respond as well to insulin.
Clinically Proven 40:1 Inositol for Hormonal Balance, Cycle & Metabolic Support.
Shop NowWhen your cells don't respond well to insulin, your body can make more of it. In some women with PCOS, that can affect ovulation and make periods unpredictable.
With insulin resistance, your cells don't respond as well to insulin.
Extra insulin can affect hormones in the ovaries.
When ovulation is disrupted, periods may be late or skipped.
Myo and D-Chiro are two forms of inositol involved in insulin signaling. They have different roles. That's why we put them together.
Some products contain Myo alone. Hessence pairs Myo with D-Chiro, each with its own role in insulin signaling.
Involved in the way cells respond to insulin and how the ovaries function.
Involved in how insulin tells the body to store sugar.
2,000 mg Myo + 50 mg D-Chiro, with both doses on the label.
Four capsules per serving. Thirty daily servings per bottle.
Read their experiences with Hessence.
I have PCOS and have struggled for years. I've tried other inositol supplements before, and nothing seemed to make much of a difference. Before purchasing, I read all the reviews because I wanted to feel hopeful, but I was honestly skeptical. I'm now in my second month, and I started noticing changes in how I felt within the first month. After spending so long feeling like nothing was working, that meant everything to me.
For years, I struggled with horrible fatigue and felt like my life was on hold. There were times I barely had the energy to leave my bed, let alone enjoy everyday activities. Over the last two months, I've started feeling more like myself. I'm finally finding the energy to go out, make plans, and do things I hadn't felt well enough to do in years. I still have my challenges, but feeling like I can enjoy life again has been such an emotional experience.
My PCOS affected so much of my life that I eventually had to take a break from college. For years, I felt like I was constantly fighting my own body. Now I'm actually hopeful about going back to school, joining a gym, and doing all the things I've missed. I know I still have PCOS, and not everything is perfect, but I'm excited about the future again. After feeling hopeless for so long, that change means more than I can explain.
| Compare | Hessence (40:1) | Myo-only formula |
|---|---|---|
| Myo-Inositol | 2,000 mg | Varies by product |
| D-Chiro Inositol | 50 mg | Not included |
| Defined Myo:D-Chiro ratio | 40:1 | Not applicable |
| Both forms on the label | Yes | No |
| Third-party tested | Yes | No |
Your hormones aren't the only factor. In some women with PCOS, insulin resistance can affect ovulation. When ovulation is irregular, your period can be late, skipped, or unpredictable.
Insulin helps your body handle sugar. When your cells stop responding well, your body may make extra insulin. Higher insulin can affect the hormones involved in ovulation.
Myo-Inositol is involved in how cells respond to insulin. It also plays a role in how the ovaries work. Each serving of Hessence contains 2,000 mg.
D-Chiro is a different form of inositol. It's involved in insulin signals linked to how the body stores sugar. Each serving of Hessence contains 50 mg.
Myo and D-Chiro play different roles in insulin-related signaling. Hessence pairs both forms in one formula. If your last bottle contained Myo alone, it wasn't this combination.
It means 40 parts Myo for every 1 part D-Chiro: 2,000 mg Myo + 50 mg D-Chiro per four-capsule serving. It's the ratio of the ingredients, not 40 times the strength.
Everyone responds differently. Studies often look at changes over several months, not days, and no specific outcome is guaranteed. Tracking your cycle can help you see your own pattern.
One serving is four capsules, with 2,000 mg Myo and 50 mg D-Chiro. A bottle contains 30 daily servings. Follow the label. Check with your healthcare professional if you take medication or are pregnant or breastfeeding.